Kidney failure risk tool
Kidney Failure Risk Calculator: 4-Variable KFRE
Estimate the probability of treated kidney failure within two and five years using four clinical variables.
This calculator is for adults with established CKD and eGFR below 60. It is a population risk estimate, not a diagnosis or a prediction for one individual. Discuss the result with a nephrologist or other qualified clinician.
Who should use the 4-variable KFRE?
The equation was developed for adults with established chronic kidney disease and an eGFR below 60 mL/min/1.73 m². It combines age, sex, eGFR, and urine albumin-to-creatinine ratio (uACR) to estimate the risk of treated kidney failure.
How to interpret the result
The result is a population-based estimate, not a diagnosis and not a guarantee of what will happen to one person. A nephrology team should interpret it alongside repeated laboratory results, symptoms, comorbidities, treatment goals, and the cause of CKD.
Why uACR matters
uACR measures albumin in urine and adds information about kidney damage that eGFR alone cannot provide. Use a recent laboratory result and ask your clinician whether it needs to be repeated to confirm persistence.